Construction of Y376C-FGFR4 eukaryotic expression plasmid and its biological activity in HEK293 cell

• 来源期刊: 生物化学与生物物理学报（英文版）
• 年，卷（期）: 2013,（10）
• 页码范围: 889-892
• 页数: 4页
• 语种: 英文
• DOI: 10.1093/abbs/gmt091.

摘要

Fibroblast growth factor receptor (FGFR),a member of tyrosine kinase family,is composed of three domains,including a three-extracellular Ig-like domain,a transmembrane domain,and a tyrosine kinase domain.FGFR4 is a member of the FGFR family,which plays a pivotal role in tumorigenesis.It has been found that FGFR4 plays an important role in melanoma,prostate cancer,head and neck cancer,and primary liver cancer malignant development [1,2].The poor response of FGFR4 to chemotherapy has been associated with its over-expression [3].