PGC7, H3K9me2 and Tet3: regulators of DNA methylation in zygotes

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2013,（1）
• 页码范围: 6-9
• 页数: 4页
• 语种: 英文
• DOI: 10.1038/cr.2012.117

摘要

In zygotes,a global loss of DNA methylation occurs selectively in the paternal pronucleus before the first cell division,concomitantly with the appearance of modified forms of 5-methylcytosine.The adjacent maternal pronucleus and certain paternallyimprinted loci are protected from this process.Nakamura et al.recently clarified the molecular mechanism involved:PGC7/Stella/Dppa3 binds to dimethylated histone 3 lysine 9(H3K9me2),thereby blocking the activity of the Tet3 methylcytosine oxidase in the maternal genome as well as at certain imprinted loci in the paternal genome.