Long Lasting Efficiency of Monthly Vinblastine in a Case of Relapsed Anaplastic Large Cell Lymphoma

• 作者: Didier Frappaz Matthias Schell Nathalie Bleyzac Perrine Marec Bérard Ratha Mlis
• 来源期刊: 血液病期刊(英文)
• 学科: 医学
• 关键词: ANAPLASTIC Large Cell LYMPHOMA VINBLASTINE
• 年，卷（期）: 2013,（2）
• 页码范围: 63-64
• 页数: 2页
• 分类号: R73

摘要

Nearly 40% of children with Anaplastic Large cell lymphomas will relapse after a first-line strategy with short-pulse chemotherapy and reach a second remission in 30% to 60% with second line therapies including maintenance treatment with vinblastine or allogeneic hematopoietic stem-cell transplantation. The authors report a heavily pretreated case in second relapse who was maintained in third remission for 8 years with monthly vinblastine. He relapsed 16 weeks after discontinuation. This case demonstrates that monthly treatment with vinblastine may be sufficient to maintain a minimal disease. Oral compounds are now available and should be discussed in such situations.