Neuroendocrine differentiation of prostate cancer

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2013,（3）
• 页码范围: 328-332
• 页数: 5页
• 语种: 英文
• DOI: 10.1038/aja.2013.7

摘要

Prostate cancer is a major health risk for men in Western countries as it is the most common malignancy and the second leading cause of cancer-related deaths.In some countries where prostate cancer is traditionally uncommon such as China,the incidence of prostate cancer has also shown a dramatic increase in recent years. Low grade,organ-confined prostate cancers are curable by surgery or radiation therapy.For patients with recurrent or metastatic prostate cancer,hormonal therapy,by inhibiting androgen production and/or blocking androgen receptor (AR) function,is the treatment of choice.Unfortunately,hormonal therapy is not curative and the cancer nearly always recurs after an initial period of response and inevitably progresses to the castra-tion resistant stage.