A genomic approach to active surveillance: a step toward precision medicine

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2013,（3）
• 页码范围: 340-341
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/aja.2012.140

摘要

Although there is agreement in urologic circles that early detection and aggressive treatment of higher grade cancers reduces prostate cancer-specific mortality,the widespread overtreatment of low grade,nonaggressive disease led the US Preventative Services Task Force to recommend against routine screening.1 There are accumulating data from several institutions on an altemative management strategy called ‘active surveillance'.2Active surveillance is defined as expectant management with curative intervention delayed until signs of tumor progression;its main advantage is that it avoids overtreatment of indolent disease,thereby restricting the cost and morbidity of curative-intent treatments only to those who have potentially life-threatening cancers.Despite the favorable outcomes reported for surveillance,its clinical use is limited,with ＞90％ of men in the US diagnosed with potentially indolent disease undergoing immediate treatment with radiation or surgery.2