Beating in a dish: new hopes for cardiomyocyte regeneration

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2013,（3）
• 页码范围: 314-316
• 页数: 3页
• 语种: 英文
• DOI: 10.1038/cr.2012.163

摘要

As a leading cause of death worldwide,heart failure represents a severe medical condition which renders both a challenge and opportunity to the field of regenerative medicine.One major cause of heart failure is the massive loss or dysfunction of cardiomyocytes after myocardial infarction.In addition,chronic cardiac disorders,such as hypertension and aging,also lead to progressive cardiomyocyte loss,and eventually to the development of heart failure.Unlike some other vertebrates,who are able to regenerate their hearts after injury,the adult mammalian heart is believed to have very limited innate regenerative capacity,making it virtually impossible for the injured heart to cure itself.