Lessons from zebrafish on reprogramming the epigenetic code after fertilisation

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2013,（5）
• 页码范围: 582-583
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/aja.2013.91

摘要

Methylation of cytosine bases encodes epigenetic information that governs lineage-specific patterns of gene expression.Remodelling the methylated genome accompanies major transitions during embryo development,including fertilisation,blastulation and gastrulation.The first whole genome epigenetic maps of this modification across these embryonic transitions in a metazoan has been reported in the zebrafish,and shows surprising differences from the long-accepted models developed from more limited analyses of mammalian embryos.The analysis of the zebrafish shows a primacy of the sperm's epigenome as a blueprint for creating the embryonic epigenome.The study illustrates the strengths of comparative approaches to complex biological questions.