Psoriatic skin lesions induced by tumor-necrosis-factor-alpha-therapy

• 作者: Antonia Cosima Faul Birgit Angela Aigner Christian Folwaczny Johannes Ring Rüdiger Hein Sabine Gisela Pl?tz
• 来源期刊: 临床医学病理报告(英文)
• 学科: 医学
• 关键词: INFLIXIMAB PSORIASIS TNFΑ INHIBITORS Crohn’s Disease ANKYLOSING SPONDYLITIS Side Effects
• 年，卷（期）: 2013,（1）
• 页码范围: 85-88
• 页数: 4页
• 分类号: R5

摘要

A 46-year-old, caucasian woman suffering from Crohn’s disease and a 35-year-old woman suffering from ankylosing spondylitis were treated with the TNFα blocker infliximab and developed psoriasiform skin lesions. The pathophysiology of this paradoxical clinical response as a newly recognized adverse effect of TNFα antagonists is unknown. According to the literature, this type of newly triggered psoriasis may occur any time after initiation of TNFα antagonist therapy and responds to classic antipsoriatic treatment. The phenomenon warrants attention, especially when considering anti-TNFα treatment in various skin diseases besides psoriasis.