Overcoming the chromatin barrier to end resection

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2013,（3）
• 页码范围: 317-319
• 页数: 3页
• 语种: 英文
• DOI: 10.1038/cr.2012.148

摘要

DNA double-strand breaks (DSBs) are highly cytotoxic lesions that must be repaired appropriately to prevent the formation of deleterious chromosome rearrangements associated with tumorigenesis.Cells use two major pathways to repair DSBs:homologous recombination (HR) and non-homologous end joining (NHEJ).Repair by HR requires a homologous donor duplex and is considered a high-fidelity process,whereas the homology-independent end joining pathway involves re-ligation of the broken ends and is more error prone.