Caught in translation: innate restriction of HIV mRNA translation by a schlafen family protein

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2013,（3）
• 页码范围: 320-322
• 页数: 3页
• 语种: 英文
• DOI: 10.1038/cr.2012.155

摘要

Human immunodeficiency virus type 1 (HIV-1) is an RNA virus that infects human T-cells,macrophages and dendritic cells.A part of the viral replication cycle is to transcribe the RNA genome into a proviral DNA copy that is actively integrated into the host cell genome.Subsequently,the cell produces spliced viral mRNAs that are transcribed into viral proteins using the host machinery.In a recent paper published in Nature,Li et al.[1] describe schlafen (SLFN)11 as a restriction factor for HIV,acting by regulating viral protein synthesis (Figure 1).