Dendritic self-avoidance: protocadherins have it covered

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2013,（3）
• 页码范围: 323-325
• 页数: 3页
• 语种: 英文
• DOI: 10.1038/cr.2012.137

摘要

The ability of the mammalian brain to accurately encode and process information depends on the formation of highly precise wiring of dendritic and axonal processes.One important principle of dendrite and axon organization is termed self-avoidance,which refers to the tendency of branches from the same cell (or sister branches) to spread from one another with minimal crossing or overlap [1].Self-avoidance ensures that dendritic territories are covered completely and yet non-redundantly (Figure 1).Conversely,arbors from different neurons can overlap freely with one another,or co-exist.