Is prostate cancer a Lynch syndrome cancer?

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2013,（5）
• 页码范围: 588-589
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/aja.2013.87

摘要

The question of whether men with an inherited genetic condition called Lynch syndrome have an increased risk of developing prostate cancer has been controversial.It is important to answer this question,for understanding the role of DNA mismatch repair in carcinogenesis of prostate as well as for clinical implications for screening. Lynch syndrome,previously known as hereditary non-polyposis colorectal cancer,1 is an autosomal dominantly inherited cancer susceptibility disorder caused by germline mutations in the DNA mismatch repair (MMR) genes,MLH1,MSH2,MSH6 and PMS2.Carriers of MMR gene mutations have a substantial burden of increased risk for cancers of the colon,rectum,endometrium,stomach,ovary,ureter,renal pelvis,brain,small bowel and hepatobiliary tract which generally occur at younger ages than for the general population.2 In a recent publication in the Journal of Clinical Oncology,Raymond et al.3 reported that men carrying MMR gene mutations have a twofold increased risk of prostate cancer compared with the general population.