Splenic Marginal Zone Lymphoma in a Patient with Positive Hepatitis B Virus Serology

• 作者: Bokhari Syed Eden Dewi Qureshi Iman
• 来源期刊: 血液病期刊(英文)
• 学科: 医学
• 关键词: SPLENIC MARGINAL Zone LYMPHOMA HEPATITIS B
• 年，卷（期）: 2013,（4）
• 页码范围: 105-107
• 页数: 3页
• 分类号: R73

摘要

We present a case in which an elderly woman diagnosed with a splenic marginal zone lymphoma (MZL) was found to have positive Hepatitis B serology. Link with Hepatitis C virus is well documented but reports of association of Hepatitis B virus (HBV) with splenic marginal zone lymphoma are still emerging. A 69-year-old lady presented with weight loss, pancytopenia and marked splenomegaly. Prior to commencing treatment, Hepatitis B serology confirmed Hepatitis B infection. She was treated with Chlorambucil along with anti-hepatitis B prophylaxis and HBV PCR monitoring. She had an excellent response to treatment with resolution of symptoms and splenomegaly. This case highlights the importance of testing for hepatitis B serology in patients diagnosed with splenic MZLs as causative agent. Although the association between HCV is well documented in the literature, a relationship between HBV may also be important. Also, chemotherapy +/- Rituximab for splenic MZL is associated with the reactivation of latent infections;hence providing prophylactic cover for pre-existing latent HBV infection may be required to prevent reactivation as in this case.