Background: Neonatal acute hematogenous osteomyelitis is very rare in clinical research. Early diagnosis and treatment to reduce the sequelae is very important. The purpose is to introduce a rare and special case to medical workers, so that readers know how to diagnose and treat such special cases. Methods: Through the clinical manifestations, imaging studies and the results in blood culture. Results: There were no adverse sequelae after effective antibiotics, which were discharged. Conclusion: There is great importance in early diagnosis and treatment of neonatal osteomyelitis.