PRSS3/mesotrypsin in prostate cancer progression:implications for translational medicine

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2013,（4）
• 页码范围: 439-440
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/aja.2013.14

摘要

Prostate cancer morbidity and mortality are caused by metastasis to other vital organs and tissues.Metastatic prostate cancer is a terminal disease in need of improved therapies.Hockla et al.have identiffed prostate cancer cell upregulation of the digestive protease PRSS3/mesotrypsin in association with metastasis and recurrence.Gene silencing of PRSS3 led to pronounced reductions in invasion and metastasis in cell culture and in an orthotopic mouse model of prostate cancer.Importantly,a recendy developed inhibitor of mesotrypsin was equally effective in suppressing invasion.These results identify mesotrypsin as a potential therapeutic target in metastatic prostate cancer.