Novel Synthesis Approach and Antiplatelet Activity Evaluation of 6-Arylmethyleneamino-2-Alkylsulfonylpyrimidin-4(3<i>H</i>)-one Derivatives and Its Nucleosides

• 作者: Abdel-Rhman B. A. El-Gazzar Abdulrahman G. Alshammari
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: Natural ASSET Financial Value Neural Network
• 年，卷（期）: 2013,（3）
• 页码范围: 28-40
• 页数: 13页
• 分类号: O6

摘要

A new and efficient procedure has been designed for the preparation of 6-arylmethylene-amino-2-alkyl sulfonyl-pyrimidine. The first alkylthio group was introduced into the pyrimidine ring by S-alkylation. The introduction of the second one was successfully achieved using the phosphorous oxychloride method to afford 4-chloro-2-alkylthio-pyrimidines. Subsequent nucleophilic displacement by the corresponding alkylamines followed by glycoside bromide addition conveniently gave a series of the target compounds. Thus, the two same or different alkylamino groups were easily introduced into the pyrimidine ring through the two different approaches. The human anti-platelet aggregation activity of the newly synthesized compounds was also described.