Non-invasive metabolomic profiling of Day 3 embryo culture media using near-infrared spectroscopy to assess the development potential of embryos

• 来源期刊: 生物化学与生物物理学报（英文版）
• 年，卷（期）: 2013,（12）
• 页码范围: 1074-1078
• 页数: 5页
• 语种: 英文
• DOI: 10.1093/abbs/gmt115

摘要

The success rate and multiple pregnancy rate are two important issues emerging in assisted reproductive technology cycles [1].It is usually used to increase the number of embryos;however,it increases the risk of multiple pregnancies.Therefore,the key point to improve the success rate is to select the best-quality embryos [2-4].Currently,noninvasive embryo selection emerges which is primarily based on morphological criteria,such as pronuclear morphology [5-7],appearance of much fragmentation [8-11],and multinucleation of blastomeres [12] and unequal-sized blastomeres [13-16] by light microscopy analysis.Although it is easy and convenient to obtain data by using these morphological criteria which are known to contribute to pregnancy outcomes,they have limited predictive value for ongoing pregnancy and the accuracy to select embryos of high reproductive potential almost depends on the experience of embryologist [17-19].Therefore,new selection techniques are needed [20,21].