Castrate-tolerant cells: what are the implications for the treatment of localized prostate cancer?

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2013,（6）
• 页码范围: 708
• 页数: 1页
• 语种: 英文
• DOI: 10.1038/aja.2013.94

摘要

More effective treatment of prostate cancer relies on eliminating cells that survive androgen withdrawal therapy.The discovery that castrate-tolerant tumour cells pre-exist in localized prostate cancer,prior to androgen withdrawal or progression to castrate-resistant disease,supports the notion that neo-adjuvant therapies might be considered in the management of early stage prostate cancer.Advances in our ability to xenograft human prostate cancer provides a unique model system to study individual patient responses and test the preclinical efficacy of novel compounds for men with localized disease.