aPKC ι/λ: a potential target for the therapy of Hh-dependent and Smo-inhibitor-resistant advanced BCC

• 来源期刊: 生物化学与生物物理学报（英文版）
• 年，卷（期）: 2013,（7）
• 页码范围: 610-611
• 页数: 2页
• 语种: 英文
• DOI: 10.1039/abbs/gmt053

摘要

Basal cell carcinoma (BCC),a skin cancer,is the most common malignancy in white people [1,2].Although mortality is low as BCC rarely metastasizes,people suffering from BCC are at high risk of developing other malignancies [3].Given its low metastatic potential,treatment of BCC focuses on local control,including surgical and non-surgical measures [3,4].In the best hands,the 5-year cure rates of excision,curettage and cautery,and cryosurgery are 95％ or higher [3].