Set them free: F-box protein exchange by Cand1

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2013,（7）
• 页码范围: 870-871
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/cr.2013.55

摘要

Cand1 (Cullin-associated and neddylation-dissociated protein 1)has long been known as a regulator of SCF ubiquitin iigases,but details remained puzzling due to conflicting results from in vitro and in vivo experiments.Three recent reports,one in Cell and two in Nature Communications,propose Cand1 as a protein exchange factor with interesting mechanism that reconciles Cand1genetics and biochemistry.