Chromoplexy: a new paradigm in genome remodeling and evolution

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2013,（6）
• 页码范围: 711-712
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/aja.2013.109

摘要

Early massively-parallel sequencing studies have revealed the mutational landscape of protein-coding genes in prostate cancer.However,most of these studies have not explored the extensive influence of genomic rearrangement in prostate cancer.In a recent Cell article,Baca and colleagues used whole-genome sequencing to tackle this issue,comprehensively surveying the abundance of genomic rearrangements present in a large cohort of 57 prostate cancers.They characterized a wide-spread phenomenon termed ‘chromoplexy',which may drive cancer evolution through the phenomena of punctuated equilibrium by concurrently dysregulating numerous cancer genes across multiple chromosomes.