Virtual drug design: Skp1-Skp2 inhibition targets cancer stem cells

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2013,（6）
• 页码范围: 717-718
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/aja.2013.115

摘要

The dysregulation of pathways regulating cellular function is a frequent hallmark of cancer and the development of specific pathway inhibitors that alter tumor growth and progression are the focus of multiple recent studies.E3 ubiquitin ligases are a large group of diverse protein enzymes that specifically target proteins for clearance,and their importance to normal cellular function is illustrated in the many diseases associated with their loss of function or inappropriate targeting.S-phase kinase-associated protein 2 (Skp2) is an F box protein that plays critical roles in cellcycle progression,senescence,metabolism,and acts as an Skpl-Cullin-l-F box (SCF) ubiquitin ligase substrate recognition factor.