New Method of Palladium Metal Trapping through Resins in Antiviral Drug: Valacyclovir HCl

• 作者: Bojja Ramachandra Reddy Ghanta Mahesh Reddy Keshava Navin Kumar Reddy Mayur D. Khunt Murugulla Adharvana Chari V. V. N. K. V. Prasada Raju Vurimidi Himabindu
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: VALACYCLOVIR HYDROCHLORIDE ANTIVIRAL Drug N-Phthalimide-L-Valine Ester Monomethylamine Commercially Scalable Process Less Cycle Time
• 年，卷（期）: 2013,（4）
• 页码范围: 251-255
• 页数: 5页
• 分类号: O6

摘要

This process describes a novel technique for effective trapping of “Pd” metal through resins during the process development of L-valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl) methoxy] ethyl ester, and mono hydrochloride known as a Valacyclovir hydrochloride (1). This technique is suitable for large-scale production of 1 and it is described here Pd metal trapping by using different resins.