The IκB family member Bcl-3 stabilizes c-Myc in colorectal cancer

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2013,（4）
• 页码范围: 280-282
• 页数: 3页
• 语种: 英文
• DOI: 10.1093/jmcb/mjt020

摘要

Dear Editor, The proto-oncogene c-myc has been thought to play a critical role during the tumor-initiating process in multiple human cancers.Among others,colorectal cancer (CRC) is particularly associated with deregulated expression of c-Myc (Meyer and Penn,2008;Wilkins and Sansom,2008).Physiologically,Myc mRNA and protein levels are tightly regulated,and the Myc protein is highly unstable.The high levels of Myc protein in human CRC could be attributed to the altered Myc turnover and aberrant transcriptional activation of the myc genes (Ikegaki et al.,1986;Welcker and Clurman,2008).