Doubt about antidepressant-like effect

• 来源期刊: 生物医学研究杂志（英文版）
• 年，卷（期）: 2013,（3）
• 页码范围: 245-248
• 页数: 4页
• 语种: 英文
• DOI: 10.7555/JBR.27.20120055

摘要

Dear Editor: Extensive studies have measured antidepressantlike effects of chemical compounds to discover new drugs for depression treatment or to clarify the molecular mechanisms of depression.Most useful antidepressants including tricyclics,selective serotonin reuptake inhibitors (SSRIs),noradrenaline reuptake inhibitors (NRIs),serotonin and noradrenaline reuptake inhibitors (SNRIs),and monoamine oxidase inhibitors (MAOIs) exert antidepressant-like effects in forced swimming test (FST) in mice and rats[1].However,it remains unanswered whether the observed antidepressant-like effects are real antidepressant effects as seen in those by antidepressant drugs used in clinic.