COUP-TFII, a prognostic marker and therapeutic target for prostate cancer

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2013,（3）
• 页码范围: 360-361
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/aja.2013.12

摘要

Despite much recent progress,prostate cancer is still the most common malignancy in men of the Western world.Most prostate tumors are initially indolent,but some of them rapidly become aggressive and metastatic.The absence of an effective prognostic marker to distinguish the aggressive versus the indolent tumors has led to a major concern for the accuracy of the diagnosis of prostate cancer in patients.1 This prognostic challenge could be addressed by further understanding the underlying mechanism of prostate cancer malignance.PTEN mutation and genomic alterations in the PI3K-signaling pathway are the most common geneticalterations reported in prostate cancer patients.