The good and bad of microglia/macrophages: new hope in stroke therapeutics

• 来源期刊: 中国药理学报（英文版）
• 年，卷（期）: 2013,（1）
• 页码范围: 6-7
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/aps.2012.178

摘要

Ischemic stroke contributes up to 80％ of total stroke incidence and is one of the leading causes of death and disability worldwide[1,2].Noteworthily,the inflammatory responses triggered after ischemic stroke often amplify and exacerbate the ischemic lesion[2].Insufficient blood supply to brain cells initiates the pathophysiology of ischemic stroke and results in a densely ischemic core surrounded by a poorly perfused region termed ischemic penumbra.Cells within the ischemic area become deprived of oxygen,glucose,and other nutrients.Since oxygen and glucose are critical fuels for brain cell survival,lack of these factors leads to dysfunction of neurons,glial cells,endothelial cells,and pericytes.