Niche-less maintenance of HSCs by 2i

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2013,（4）
• 页码范围: 458-459
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/cr.2013.14

摘要

Maintenance of hematopoietic stem cells (HSCs) in vitro has been believed to be difficult due to a lack of complete understanding of HSC quiescence maintained by the niche.Recent evidence suggests that in vitro maintenance of human and mouse long-term HSCs (LT-HSCs)is possible through dual inhibition (2i) of both GSK-3 and mTOR in the absence of cytokines,serum,or feeder cells.