Directing transcription to the right way

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2013,（10）
• 页码范围: 1153-1154
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/cr.2013.100

摘要

How cells ensure that productive transcription from divergent promoters is limited to the downstream protein-coding region is an important question in the transcription field.A recent study in Nature proposed an answer by revealing that the upstream antisense transcripts undergo early termination through the polyadenylation signal-dependent pathway,and the downstream sense transcripts are protected from premature cleavage by U1 small nuclear ribonucleoprotein (snRNP).