Treating liver cancer with antibiotics?

• 来源期刊: 中国药理学报（英文版）
• 年，卷（期）: 2013,（8）
• 页码范围: 989-990
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/aps.2013.102

摘要

Obesity is one of the most prevalent health concerns over the past few decades.Besides diabetes and cardiovascular disease,obesity is also connected to multiple types of cancers[1,2].However,the mechanism underlying obesity-related cancers is unclear.Previous research found that obesity alters the microbiota grown in the gastrointestinal tract[3],where the microbes produce inflammatory metabolites[4].And obesity-induced inflammation is involved in liver cancer[5].Recently,Yoshimoto et al uncovered the missing link,by which obesity promotes the production of proinflammatory and carcinogenic bile acids via shaping gut microbiota,and leads to hepatic inflammation and hepatocellular carcinoma (HCC)[6] (Figure 1).