Identification,characterization and targeting of Docetaxel-resistant prostate cancer cells

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2013,（1）
• 页码范围: 83-84
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/aja.2012.133

摘要

Men with castration-resistant prostate cancer exhibit resistance to chemotherapeutic agents such as Docetaxel.Defining the mechanisms of resistance to Docetaxel is critical for treating advanced disease.In a new study,Carlos Cordon-Cardo and colleagues determine that Docetaxel-resistant prostate cancer cells rely on the Notch and Hedgehog signaling pathways for their survival.These findings provide a rationale for the inhibition of Notch and Hedgehog pathways in Docetaxel-resistant prostate cancer.The authors demonstrate that Docetaxelresistant cells can propagate tumors and may exist prior to treatment,suggesting that Notch/Hedgehog pathway inhibition in combination with Docetaxel may prevent treatment-resistance.