The imbalance of IL-18/IL-18BP in patients with systemic juvenile idiopathic arthritis

• 来源期刊: 生物化学与生物物理学报（英文版）
• 年，卷（期）: 2013,（4）
• 页码范围: 339-341
• 页数: 3页
• 语种: 英文
• DOI: 10.1093/abbs/gmt007

摘要

Systemic JIA (SJIA) is one subtype of juvenile idiopathic arthritis (JIA) that is a leading cause of short-term and long-term disability in children [1].Although SJIA represents only 10％-20％ of all cases of JIA,it accounts for more than two-thirds of the mortality associated with this condition [2].The etiology and pathogenesis of SJIA remain unknown.Further understanding of SJIA pathogenesis may facilitate new therapeutic approaches. Interleukin-18 (IL-18) was originally identified as an interferon gamma (IFN)-γ-inducing factor,and IL-18 can induce INF-γ production by splenocytes,hepatic lymphocytes,and type 1T helper (Thl) cell clones [3].IL-18 levels have been shown to be abnormal in some inflammatory diseases and in autoimmune diseases.IL-18 expression has been reported to be up-regulated in lupus nephritis (LN),type 1 diabetes,and other autoimmune diseases [4].