Making T cells functional: a new solution for the athymic BMT recipients

• 来源期刊: 中国药理学报（英文版）
• 年，卷（期）: 2013,（2）
• 页码范围: 189-190
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/aps.2012.193

摘要

Thymus has long been known to be the site of T cell development and is required for the generation of a T cell repertoire[1].However,the adult bone marrow transplant (BMT) or the elderly patients suffer from a loss of thymic function resulting in low T cell production,susceptibility to infection and tumour,and a poor survival for a diversity of diseases[2].Increasing thymic function and/or extrathymic T-cell development can thus play an important role in patients with limited thymic function.