Crystal structure of L,D-transpeptidase LdtMt2 in complex with meropenem reveals the mechanism of carbapenem against Mycobacterium tuberculosis

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2013,（5）
• 页码范围: 728-731
• 页数: 4页
• 语种: 英文
• DOI: 10.1038/cr.2013.53

摘要

Dear Editor, Tuberculosis (TB),an infectious disease caused by the bacillus Mycobacterium tuberculosis,leads to substantial mortality worldwide [1].The emergence of multidrugresistant (MDR) and extensively drug-resistant (XDR) strains of M.tuberculosis has challenged conventional anti-TB therapy and threatens global disease control of TB [2,3].The development of new anti-TB drugs is urgently required [4].β-lactams are effective antibiotics widely used to treat bacterial infections;however,so far no effective anti-TB antibiotics have emerged from this class of drugs.Previous studies have indicated that an important reason for the lack of effective β-lactam anti-TB antibiotics is the presence of a chromosomallyencoded class A (Ambler) β-lactamase,BlaC,in M.tuberculosis [5].