Proliferation and differentiation of mouse embryonic stem cells lacking all lamins

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2013,（12）
• 页码范围: 1420-1423
• 页数: 4页
• 语种: 英文
• DOI: 10.1038/cr.2013.118

摘要

Dear Editor, Lamins are the major components of the nuclear lamina (NL),which is located underneath the inner nuclear membrane [1].Diverse array of functions have been assigned to lamins,and alterations of lamins are associated with a number of human diseases [2].Of the three lamin genes in mammals,Lmna expresses all isoforms of Atype lamins,referred to as lamin-A/C,through altemative splicing,while Lmnbl and Lmnb2 express B-type lamins.Despite subtype-specific sequence variations and different expression patterns,lamin proteins exhibit overall sequence similarity.Therefore,a potential functional redundancy among different lamin proteins has made it difficult to precisely address the role of lamins in mammals.