Simultaneous determination of ternary cephalosporin solutions by Raman spectroscopy

• 来源期刊: 中国光学快报（英文版）
• 年，卷（期）: 2013,（12）
• 页码范围: 80-82
• 页数: 3页
• 语种: 英文
• DOI: 10.3788/COL201311.123001

摘要

Cephalosporins are widely used as veterinary and human antibiotics.However,cephalosporin abuse is harmful to human health and causes allergic reactions or antibiotic resistance.We investigate a method featuring Raman spectroscopy and chemometrics to quantify mixture solutions of three typical cephalosporins,namely,ceftriaxone,cefotaxime sodium,and cefazolin sodium.Partial least-squares regression models are built on spectral data that are preprocessed by various methods.With prediction relative errors within 5％ and high correlation coefficients of 0.998,we demonstrate that Raman spectroscopy combined with multivariate analysis is feasible for use in the quantitative determination of cephalosporin solutions.