The past decade has witnessed the significantly increasing impact of the Chinese chemical community worldwide and the Chinese chemists are playing an irreplaceable important role.This is reflected by not only the increased number but also the improved quality of scientific publications.Some top level original works have opened new fields or led the frontier of field.These creative works were benefited from the innovative research methods.Therefore,we planned to organize this special topic on Chemical Methodology at the very beginning of this year and received positive support from leading Chinese chemists.Forty chemists contributed to this special issue,including 15 papers about synthetic or fabrication methods,12 papers on theoretical methods,and 13 papers on instrumentation or research methodologies.According to the language of the original submission,21 papers in English of this special topic are published on this issue,and the rest 19 papers in Chinese were published on Volume 43,Issue 12 of SCIENTIA SINICA Chimica.