Effect of vitamin A and E on carbohydrate and lipid metabolism in diet-induced obese wistar rats

• 作者: Ahmed Farag Elkirdasy Hossam Fouad Attia Mohamed Mohamed Ahmed Mohamed Mohamed Soliman Samir Ahmed El-Shazly Tamer Ahmed Ismail
• 来源期刊: 生命科学与技术进展(英文)
• 学科: 医学
• 关键词: VITAMIN A and E Lipid METABOLISM CARBOHYDRATE METABOLISM Gene Regulation WISTAR Rats
• 年，卷（期）: 2014,（1）
• 页码范围: 4-11
• 页数: 8页
• 分类号: R5

摘要

In the present study, we investigated the biochemical alterations and gene expression of carbohydrate and lipid metabolism after oral administration of vitamin A and E for 2 months in diet-induced obese Wistar rats. Vitamin A and E administration reduced significantly the increase in body weight and food intake and normalized the alterations in lipid profiles in obese rats compared to normal rats. Moreover, both vitamins decreased the fat accumulation in liver tissues of obese rats. Finally, they up-regulated mRNA expression of Pyruvate Kinase (PK) and Glucose Transporter-2 (GLUT-2), and increased lipolysis and cholesterol metabolism through up-regulation of lipoprotein lipase (LPL), Sterol Responsible Element Binding Protein-1a (STREBP-1a) and STREBP-1c mRNA expression. In conclusion, vitamin A and E regulate gene expression of carbohydrate and lipid metabolism, and also ameliorate changes associated with obesity induced by high fat diet in Wistar rats.