Control of the hematopoietic stem cell state

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2014,（1）
• 页码范围: 3-4
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/cr.2013.139

摘要

Several studies have demonstrated the clonal transmission of distinct differentiation and self-renewal properties in hematopoietic stem cells during the regeneration of blood production in transplanted recipients.A recent publication now identifies Vwf expression as a discriminating marker of a hematopoietic stem cell state that is primed for platelet production in response to thrombopoietin,but also subject to developmental and other,as yet undefined,cues.