Analysis of Chicken T Cell-Mediated Responses on Thymus after Immune Stress

• 作者: Cai Zhang Fangxiang Li Jiangyan Duan Min Liu Yaju Xue Yufang Cao Yufei Yang Zhenhu Jia
• 来源期刊: 基于免疫的治疗疫苗和抗菌期刊(英文)
• 学科: 医学
• 关键词: T Cells CHICKEN THYMUS IMMUNOLOGICAL STRESS
• 年，卷（期）: 2014,（2）
• 页码范围: 22-28
• 页数: 7页
• 分类号: R73

摘要

In order to assess chicken T cell-mediated responses after immune stress, 200 two-week-old chickens were randomly divided into control group(C) and treatment groups (T1 and T2). The live I-type of Newcastle disease vaccine (ND) was taken as the source of immunological stress. The chickens in group (T2) were injected with overdose of live I-type Newcastle disease vaccine. After vaccination, the dynamic changes of CD4+, CD8+T cells on thymus were detected by immunohisto-chemistry. The ultra-structure of T cells on thymus of the chickens in group (T2) was observed by electron microscopic. The result showed: (1) After immune stress, from day 1 to day 5, the number of the CD4+T cells significantly declined and reached the bottom at day 5, but the number of the CD8+T cells increased dramatically and peaked at day 5. (2) After immune stress, from day 1 to day 5, part of T cells of chicken thymus came with apoptotic and pathological changes of putrescence continually. These results underscore: the immune stress can cause transient immune adjustment. These changes for chickens were the self-protection mechanism of immune system to adapt to survival and avoid immune disorder.