Roles and mechanisms of the CD38/cyclic adenosine diphosphate ribose/Ca²⁺ signaling pathway

• 作者: Jianbo Yue Richard Graeff Wenjie Wei
• 来源期刊: 世界生物化学杂志：英文版（电子版）
• 学科: 医学
• 关键词: CYCLIC adenosine DIPHOSPHATE RIBOSE CD38 Ca2+ RYANODINE receptors NICOTINAMIDE adenine di-nucleotide
• 年，卷（期）: 2014,（1）
• 页码范围: 58-67
• 页数: 10页
• 分类号: R363

摘要

Mobilization of intracellular Ca2+ stores is involved inmany diverse cell functions, including: cell proliferation;differentiation; fertilization; muscle contraction; secre-tion of neurotransmitters, hormones and enzymes;and lymphocyte activation and proliferation. Cyclic ad-enosine diphosphate ribose(cADPR) is an endogenousCa2+ mobilizing nucleotide present in many cell typesand species, from plants to animals. cADPR is formedby ADP-ribosyl cyclases from nicotinamide adenine di-nucleotide. The main ADP-ribosyl cyclase in mammalsis CD38, a multi-functional enzyme and a type Ⅱ mem-brane protein. It has been shown that many extracel-lular stimuli can induce cADPR production that leadsto calcium release or influx, establishing cADPR as asecond messenger. cADPR has been linked to a widevariety of cellular processes, but the molecular mecha-nisms regarding cADPR signaling remain elusive. Theaim of this review is to summarize the CD38/cADPR/Ca2+ signaling pathway, focusing on the recent advanc-es involving the mechanism and physiological functionsof cADPR-mediated Ca2+ mobilization.