High density lipoproteins and type 2 diabetes:Emerging concepts in their relationship

• 作者: Michael S Kostapanos Moses S Elisaf
• 来源期刊: 世界实验医学杂志
• 学科: 医学
• 关键词: Type 2 DIABETES High density LIPOPROTEINS INSULIN SECRETION βcells PARAOXONASE-1
• 年，卷（期）: 2014,（1）
• 页码范围: 1-6
• 页数: 6页
• 分类号: R

摘要

Patients with type 2 diabetes mellitus(T2DM)frequently exhibit macrovascular complications of atherosclerotic cardiovascular(CV)disease.High density lipoproteins(HDL)are protective against atherosclerosis.Low levels of HDL cholesterol(HDL-C)independently contribute to CV risk.Patients with T2DM not only exhibit low HDL-C,but also dysfunctional HDL.Furthermore,low concentration of HDL may increase the risk for the development of T2DM through a decreasedβcell survival and secretory function.In this paper,we discuss emerging concepts in the relationship of T2DM with HDL.