Individual causes and community determinants are synergic in maternal death occurrence. This study aimed to identify maternal mortality risk factors in a regional hospital. Material and Methods: This was a retrospective cohort study from data of 1807 hospitalized women. To identify maternal mortality risks factors, mortality hazard ratio (HR CI95%) has been calculated in univariate analysis and Cox proportional hazard model. Results: During hospitalization, 30 maternal deaths occurred. From Cox regression, adjusted mortality HR confirmed that women age older than 35 (HR = 2.5, CI95%: [1.2-5.7] and younger than 19 (HR = 3.02, CI95%: [1.5-6.7]);distance to hospital ≥10 Km (HR = 4.1, CI95%: [1.8-9.4];multiple deliveries (HR = 2.4, CI95%: [1.1-7.3]), less ante natal care (<3 visits) (HR = 3.03, CI95%: [0.97-9.48]);obstetrical maternal mortality directs causes (HR = 2.31, CI95%: [1.7-6.21]) and emergently reference (HR = 3.5, CI95%: [1.8-8.32]) were maternal mortality risk factors. Conclusion: In this regional hospital of low income country, identified maternal mortality factors are related to women socio-economic determinants and quality prenatal or obstetric care access. Interventions to reduce maternal mortality rate should be conducted within both household and women socio-economic status development and in maternal health and obstetric care strengthening.