Chronic disseminated candidiasis complicated with a ruptured intracranial fungal aneurysm in ALL

• 作者: Akifumi Endo Masatoshi Takagi Masayuki Nagasawa Teppei Okawa Toshiaki Ono
• 来源期刊: 世界血液学杂志
• 学科: 医学
• 关键词: DISSEMINATED CANDIDIASIS Β-D-GLUCAN FUNGAL cranial ANEURYSM Acute LYMPHOCYTIC leukemia Bone marrow transplantation
• 年，卷（期）: 2014,（2）
• 页码范围: 44-48
• 页数: 5页
• 分类号: R

摘要

An 11-year-old boy with acute lymphocytic leukemia(ALL)contracted disseminated candidiasis during induction therapy,which was complicated with rupture of a fungal cranial aneurysm.Ventricular drainage and coil embolization of a residual aneurysm in combination with intensive antifungal therapy rescued the patient.Although clinical improvement was achieved,high fever and elevated levels of C-reactive protein and?β-D-glucan continued for more than 10 mo.One year later,the ALL relapsed during maintenance therapy with methotrexate and 6-mercaptopurine.After salvage chemotherapy,the patient received unrelated bone marrow transplantation(BMT)in a non-complete remission condition and survived.During subsequent chemotherapy and BMT,no recurrence of the fungal infection was observed under the prophylactic anti-fungal therapy with micafungin.