Combination of the MODS Assay with the Sensititre<sup>TM</sup>MYCOTB Plate for Rapid Detection of MDR- and XDR-TB

• 作者: Carole McArthur Kim Dionne La’Chia Harrison Nicole Parrish Parichat Salee
• 来源期刊: 结核病研究(英文)
• 学科: 医学
• 关键词: TUBERCULOSIS Susceptibility Testing MODS MYCOTB MDR-TB XDR-TB
• 年，卷（期）: 2014,（3）
• 页码范围: 101-105
• 页数: 5页
• 分类号: R73

摘要

We combined the new SensititreTM MYCOTB test with the MODS assay for detection of MDR- and XDR-TB. Categorical agreement of the MODS assay with the critical concentrations at 3 days of incubation was highest for INH (91.4%) and RIF (100%) and at 5 days 86.7% and 94.6% for the fluoroquinolones and aminoglycosides, respectively. By combining these two methods, it is possible to identify MDR-TB in as little as 3 days and XDR- or pre-XDR-TB within 5 days.