MLKL regulates necrotic plasma membrane permeabilization

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2014,（2）
• 页码范围: 139-140
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/cr.2014.8

摘要

Recent data from two independent laboratories have shed new light on the molecular mechanisms by which mixed lineage kinase domainlike (MLKL) promotes a peculiar form of regulated necrosis known as necroptosis.Upon phosphorylation by receptor-interacting protein kinase 3 (RIPK3),MLKL appears indeed to form oligomers that localize to the plasma membrane and compromise its ability to preserve ionic homeostasis.