The Transcription Factors GATA-1 and GATA-4 Have Opposite Effects on DNA Expression Driven by an Amh Promoter

• 作者: David W. Dresser
• 来源期刊: 美国分子生物学期刊(英文)
• 学科: 医学
• 关键词: SMAT-1 Mouse Pre-Pubertal SERTOLI In Vitro AMH PROMOTER d2EGFP Transcription Factors GATA-1 GATA-4
• 年，卷（期）: 2014,（3）
• 页码范围: 150-158
• 页数: 9页
• 分类号: R73

摘要

An Amh promoter driving expression of a reporter gene (d2EGFP) has been used to analyze the role of two specific promoter transcription factor binding elements. In addition a downstream (3’) enhancer (DE) was also investigated. The transcription factors GATA-1 and GATA-4 had opposite effects, the former being incremental and the latter decremental. The quantitative balance between these two factors may provide a degree of control over the level of gene expression.