Preparation of polyclonal antibody highly specific for mouse BRD7 protein and its application

• 来源期刊: 生物化学与生物物理学报（英文版）
• 年，卷（期）: 2014,（2）
• 页码范围: 163-166
• 页数: 4页
• 语种: 英文

摘要

BRD7 was first identified as a novel bromodomain gene related to nasopharyngeal carcinoma (NPC) [1,2].Overexpression of BRD7 in NPC cells inhibits cell growth and cell cycle progression from G1 to S phase by transcriptional regulation of important molecules involved in Ras/MEK/ ERK,Rb/E2F,and β-catenin pathways [3-5].BRD7 is mainly localized in the nucleus and possesses a functional nuclear localization signal sequence [5].It has been identified as a subunit of the SWI/SNF chromatin-remodeling complexes and is involved in the regulation of transcription as a transcription factor [6,7].