Bone's dark side: mutated osteoblasts implicated in leukemia

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2014,（4）
• 页码范围: 383-384
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/cr.2014.26

摘要

Bone-lining osteolineage cells were previously implicated as contributors to hematological disorders and malignancies.A recent report in Nature now demonstrates that a specific mu tation in mouse collagen-expressingosteoblastic cells leads to MDS and AML with 100％ penetrance and is associated with strikingly similar findings in human patients. Bones are central to mammalian life in part because they are the place where the vast numbers of blood cells needing replacement each day are generated.All blood cells are derived from hematopoietic stem cells (HSC) that reside and are maintained in specific microanatomical domains in the bone marrow,the ‘HSC niches’.This HSC local microenvironment is functionally created by mesenchymal stromal cells and endothelial cells some of which are adjacent to the endosteal margins[1].