High-accuracy mapping of protein binding stability on nucleosomal DNA using a single-molecule method

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2014,（5）
• 页码范围: 438-440
• 页数: 3页
• 语种: 中文
• DOI: 10.1093/jmcb/mju033

摘要

Dear Editor, The conformation of nucleosomal DNA is significantly different from that of B-form double stranded DNA (dsDNA) (Richmond and Davey,2003).In nucleosomal DNA,specific DNA sequences are less flexible and less accessible than in free dsDNA,which might be due to the tight association of histone cores.The allosteric effect via DNA has been documented recently (Kim et al.,2013),suggesting that DNA is not merely a solid rod providing recognition sequences.